Constipation is not the only symptom that indicates you might benefit from a natural colon cleanse. It is not uncommon for hard material made of a mixture of mucous and fecal matter to become impacted on the inside walls of the colon and intestines. This causes a variety of health problems. For one thing, nutrients have a harder time absorbing into the bloodstream from the intestines. This situation, in turn, can cause a person to feel tired, depressed, and bloated.